Stem cell clinical trials have been going on for over 40 years, there has been countless journals and research papers that have revealed promising results from around the world. Please find below a small selection of the vast amount of clinical papers available.
Allogeneic clinical papers and studies
Treatment of Ankylosing Spondylitis (long term chronic inflammation of the Spine and other areas of the body) with Umbilical cord derived Stem cells. https://www.spandidos-publications.com/etm/14/2/1538?text=fulltext
Intervetebral Disc Repair with Allogeniec Stem Cells
https://pubmed.ncbi.nlm.nih.gov/27661661/
Umbilical cord derived Stem Cell for Knee Arthritis
https://pubmed.ncbi.nlm.nih.gov/30592390/
Intravenous Umbilical cord Stem Cell for Heart Failure
https://pubmed.ncbi.nlm.nih.gov/28974553/
Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells: A Randomized Controlled Trial
Allogeneic Versus Autologous Injectable Mesenchymal Stem Cells for Knee Osteoarthritis: Review and Current Status
Umbilical cord-derived mesenchymal stem cells for treating osteoarthritis of the knee: a single-arm, open-label study
https://pubmed.ncbi.nlm.nih.gov/31989258/
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose
and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392367/
Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526206/
Safety and Efficacy of the Intravenous Infusion of Umbilical cord Mesenchymal Stem Cells in Patients With Heart Failure
Adipose tissue stem cells in regenerative medicine clinical papers and studies
Human Adipose-Derived Stem Cells with Great Therapeutic Potential.
https://www.ncbi.nlm.nih.gov/pubmed/30973112
Adipose tissue stem cells in regenerative medicine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880231/
Adipose tissue-derived stem cells show considerable promise for regenerative medicine applications.
https://www.ncbi.nlm.nih.gov/pubmed/23949841
Differentiation of adipocytes and osteocytes from human adipose and placental mesenchymal stem cells.
https://www.ncbi.nlm.nih.gov/pubmed/25945239
Differentiation of mesenchymal stem cells of adipose tissue.
https://www.ncbi.nlm.nih.gov/pubmed/26072548
In vitro human adipose-derived stromal/stem cells osteogenesis in akermanite:poly-ε-caprolactone scaffolds.
https://www.ncbi.nlm.nih.gov/pubmed/23796629
Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs)
https://www.mdpi.com/1422-0067/20/10/2523
Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
https://www.futuremedicine.com/doi/10.2217/rme-2018-0161
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: A Pilot Study
Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.5966/sctm.2015-0245
Knee regenerative medicine clinical papers and studies
Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: a systematic review and meta-analysis.
https://www.ncbi.nlm.nih.gov/pubmed/25944079
Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II).
https://www.ncbi.nlm.nih.gov/pubmed/27565858/
Mesenchymal stem cell injections improve symptoms of knee osteoarthritis.
https://www.ncbi.nlm.nih.gov/pubmed/23375182
Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle, or Hip Osteoarthritis.
https://www.ncbi.nlm.nih.gov/pubmed/26058927
The potential use of mesenchymal stem cells in human meniscal repair: current insights.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367609/
Adipose-derived mesenchymal stem cells and arthroscopic surgery
https://www.orthohealing.com/procedures/lipogems/pdf/Moorman_2017.pdf
Cartilage repair techniques in the knee: stem cell therapies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630225/
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
https://pubmed.ncbi.nlm.nih.gov/30592390/
Allogeneic Versus Autologous Injectable Mesenchymal Stem Cells for Knee Osteoarthritis: Review and Current Status
Umbilical cord-derived mesenchymal stem cells for treating osteoarthritis of the knee: a single-arm, open-label study
https://pubmed.ncbi.nlm.nih.gov/31989258/
Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences
https://pubmed.ncbi.nlm.nih.gov/30159741/
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose
and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392367/
Mesenchymal Stem Cell Therapy for osteoarthritis: The Critical Role of
the Cell Secretome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361779/
Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis
Intra-articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence of Cartilage Repair
https://pubmed.ncbi.nlm.nih.gov/30455086/
Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
https://www.futuremedicine.com/doi/10.2217/rme-2018-0161
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: A Pilot Study
Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial
https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/stem.1634
Intra‐Articular Injection of Autologous Adipose Tissue‐Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo‐Controlled Clinical Trial
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0122
Intra‐Articular Injection of Autologous Adipose Tissue‐Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo‐Controlled Clinical Trial
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0122
Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.5966/sctm.2015-0245
Hip regenerative medicine clinical papers and studies
Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results.
https://www.ncbi.nlm.nih.gov/pubmed/30715002
Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review.
https://www.ncbi.nlm.nih.gov/pubmed/27229856
Mesenchymal stem cell therapy in the treatment of hip osteoarthritis.
https://www.ncbi.nlm.nih.gov/pubmed/28630737
The role of “cell therapy” in osteonecrosis of the femoral head. A systematic review of the literature and meta-analysis of 7 studies.
https://www.ncbi.nlm.nih.gov/pubmed/26220203
Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle or Hip Osteoarthritis.
https://www.ncbi.nlm.nih.gov/pubmed/26058927
Cell therapy of hip osteonecrosis with autologous bone marrow grafting.
https://www.ncbi.nlm.nih.gov/pubmed/19753178
Stem cell treatment for avascular necrosis of the femoral head: current perspectives.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986287/
Shoulder regenerative medicine clinical papers and studies
A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463777/
Back regenerative medicine clinical papers and studies
Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow.
https://www.ncbi.nlm.nih.gov/pubmed/28748380
Current understanding of safety and efficacy of stem cell therapy for discogenic pain—A systematic review of human studies.
https://www.sciencedirect.com/science/article/abs/pii/S1084208X16300064
Vetebral disc back pain: intradiscal injection reduced degeneration and improved QoL (Noriega et al 2017)
https://pubmed.ncbi.nlm.nih.gov/27661661/
Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis
Foot & Ankle regenerative medicine clinical papers and studies
Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle or Hip Osteoarthritis.
https://www.ncbi.nlm.nih.gov/pubmed/26058927
Enhanced revascularisation: enhanced revascularisation in patients with diabetic foot (Qin et al 2016) and improved neurological and functional status in patients with ischaemic stroke (Laskowitz et al 2018)
Wrist regenerative medicine clinical papers and studies
Stem Cells and Biological Approaches to Treatment of Wrist Problems.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826241/
Muscle, Joints and Tendon regenerative medicine clinical papers and studies
Beneficial Effects of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Naturally Occurring Tendinopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783421/
Adipose-Derived Stem Cell Transplant Technique for Degenerative Joint Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795060/
Skin Healing & Aesthetics regenerative medicine clinical papers and studies
Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds.
https://www.ncbi.nlm.nih.gov/pubmed/26652928
The use of stem cells in aesthetic dermatology and plastic surgery procedures. A compact review of experimental and clinical applications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799755/
Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327114/
Photoaged Skin Therapy with Adipose-Derived Stem Cells.
https://journals.lww.com/plasreconsurg/Fulltext/2020/06000/Photoaged_Skin_Therapy_with_Adipose_Derived_Stem.12.aspx
Arthritis / Osteoarthritis regenerative medicine clinical papers and studies
Osteoarthritis: repeat doses of intra-articular injection of UC-MSC significantly reduced pain and improved performance status (Matas et al 2019) and induced cartilage regeneration (Park et al 2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002157/
T cell-mediated autoimmune diseases: intravenous injection reduced inflammatory cytokines (IL1-b, IL-6, IL-8 and TNF-a) in patients with rheumatoid arthritis (Park et al 2018) and showed clinically beneficial anti-fibrotic effects in patients with systemic sclerosis (Maria et al 2016)
Autism
Stem cell therapy in autism: recent insights
Diabetes
Therapeutic potential of mesenchymal stem cells for diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570611/
Efficacy of mesenchymal stem cell therapy on glucose levels in type 2 diabetes mellitus: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/32926576/
Long term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus
Other papers
Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial
https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/sctm.20-0472
Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(19)30258-5/fulltext
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152513/
Enhanced bone repair: Significant reduction in necrotic volume of the femoral head in patients with advanced osteonecrosis (Chen et al 2016)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202807/
Chronic heart failure: enhanced LVF and QoL (Bartolucci et al 2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372053/
Liver function: improved liver function in patients with liver cirrhosis and reduction in ascites (Zhang et al 2012)
https://pubmed.ncbi.nlm.nih.gov/22320928/
Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-1583-4
Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: An updated systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/31989101/
Intra‐articular injection of culture‐expanded mesenchymal stem
cells with or without addition of platelet‐rich plasma is effective
in decreasing pain and symptoms in knee osteoarthritis: a controlled,
double‐blind clinical trial
https://pubmed.ncbi.nlm.nih.gov/31587091/
Shockwave Therapy & Stem Cells
Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells
https://pubmed.ncbi.nlm.nih.gov/23880536/
Effect of Shock Wave Treatment on Platelet-Rich Plasma Added to Osteoblast Cultures
https://www.sciencedirect.com/science/article/abs/pii/S030156291000565X
Further references
Bartolucci J, Verdugo FJ, González PL, Larrea RE, Abarzua E, Goset C, Rojo P, Palma I, Lamich R, Pedreros PA, Valdivia G, Lopez VM, Nazzal C, Alcayaga-Miranda F, Cuenca J, Brobeck MJ, Patel AN, Figueroa FE, Khoury M.Bartolucci J, et al. Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]). Circ Res. 2017 Oct 27;121(10):1192-1204.
Chen C, Qu Z, Yin X, Shang C, Ao Q, Gu Y, Liu Y.Chen C, et al. Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study.
Mol Med Rep. 2016 Nov;14(5):4209-4215.
Laskowitz DT, Bennett ER, Durham RJ, Volpi JJ, Wiese JR, Frankel M, Shpall E, Wilson JM, Troy J, Kurtzberg J, Laskowitz DT, et al. Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study. Stem Cells Transl Med. 2018 Jul;7(7):521-529.
Maria ATJ, Toupet K, Maumus M et al. Human adipose MSC as potent anti-fibrosis therapy for systemic sclerosis. J Autoimmunity 2016;70:31.39.
Matas J, Orrego M, Amenabar D, Infante C, Tapia-Limonchi R, Cadiz MI, Alcayaga-Miranda F, González PL, Muse E, Khoury M, Figueroa FE, Espinoza F, Matas J, et al. Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial. Stem Cells Transl Med. 2019 Mar;8(3):215-224.
Noriega DC, Ardura F, Hernadez-Ramajo, et al. Intervetrebral disc repair by allogeneic MSC: a randomised controlled trial. Transplantation 2017;101:1945-1951.
Park EH, Lim HS, Lee S, Roh K, Seo KW, Kang KS, Shin K, et al. Intravenous Infusion of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Rheumatoid Arthritis: A Phase Ia Clinical Trial. Stem Cells Transl Med. 2018 Sep;7(9):636-642.
Park YB, Ha CW, Lee CH, Yoon YC, Park YG.Park YB, et al. Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up. Stem Cells Transl Med. 2017 Feb;6(2):613-621.
Qin HL, Zhu XH, Zhang B, Zhou L, Wang WY.Qin HL, et al.Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot. Exp Clin Endocrinol Diabetes. 2016 Sep;124(8):497-503.
Wong KL, Lee KBL, Tai BC, et al. Injectable cultured bone marrow-derived MSC in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective randomised controlled clinical trials with 2 years’ follow-up. J Arthroscopic & Related Surgery 2013;29:2020-2028.
Zhang Z, Lin H, Shi M, Xu R, Fu J, Lv J, Chen L, Lv S, Li Y, Yu S, Geng H, Jin L, Lau GK, Wang FS.Zhang Z, et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:112-20.
